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Article

The tRNA recognition mechanism of folate/FAD-dependent tRNA methyltransferase (TrmFO).

The Journal of biological chemistry - 14 Dec 2012

Yamagami Ryota, Yamashita Koki, Nishimasu Hiroshi, Tomikawa Chie, Ochi Anna, Iwashita Chikako, Hirata Akira, Ishitani Ryuichiro, Nureki Osamu, Hori Hiroyuki

Abstract excerpt

The conserved U54 in tRNA is often modified to 5-methyluridine (m(5)U) and forms a reverse Hoogsteen base pair with A58 that stabilizes the L-shaped tRNA structure. In Gram-positive and some Gram-negative eubacteria, m(5)U54 is produced by folate/FAD-dependent tRNA (m(5)U54) methyltransferase (TrmFO). TrmFO utilizes N(5),N(10)-methylenetetrahydrofolate (CH(2)THF) as a methyl donor. We previously reported an in...

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Identifiers

PMID: 23095745
DOI: 10.1074/jbc.M112.390112
PMCID: PMC3522250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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