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tRNA m <sup>1</sup> G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10

2023-02-01

Abstract excerpt

<h4>ABSTRACT</h4> The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene ( TRMT10A ) have been linked to neurological disorders such as microcephaly and intellectual disability, as well as defects in glucose metabolism. Of the 26 tRNAs in yeast with guanosine at posit...

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Identifiers and source

Literature Corpus work
c7061057-a61a-5a72-9d88-6b4edbb9615b
DOI
10.1101/2023.02.01.526536
Open publication

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tRNA m <sup>1</sup> G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10DOI 10.1101/2023.02.01.526536
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