Article

Identification of a motif in Trm732 required for 2’- <i>O</i> -methylation of the tRNA anticodon loop by Trm7

2021-06-03

Abstract excerpt

Posttranscriptional tRNA modifications are essential for proper gene expression, and defects in the enzymes that perform tRNA modifications are associated with numerous human disorders. Throughout eukaryotes, 2’- O -methylation of residues 32 and 34 of the anticodon loop of tRNA is important for proper translation, and in humans, lack of these modifications results in non-syndromic X-linked intellectual disabilit...

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Literature Corpus work: e5288563-cc8d-5181-b51d-c7d676f75b7d
DOI: 10.1101/2021.06.03.446962

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