Article
MEG-1 and MEG-2 are embryo-specific P-granule components required for germline development in Caenorhabditis elegans.
Genetics - 1 Jan 2008
Leacock Stefanie W, Reinke Valerie
Abstract excerpt
In Caenorhabditis elegans, germ granules called P granules are directly inherited from mother to daughter and segregate with the germ lineage as it separates from the soma during initial embryonic cell divisions. Here we define meg-1 and meg-2 (maternal-effect germ-cell defective), which are expressed in the maternal germline and encode proteins that localize exclusively to P granules during embryonic germline...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Proliferation
- Cell Survival
- Cytoplasmic Granules
- Embryo, Nonmammalian
- Fertility
- Genes, Helminth
- Germ Cells
- Larva
- Mutation
- Phenotype
- Protein Binding
- Protein Transport
- Recombinant Fusion Proteins
- Temperature