Article
The N-terminal domain tethers the voltage-gated calcium channel β2e-subunit to the plasma membrane via electrostatic and hydrophobic interactions.
The Journal of biological chemistry - 11 Apr 2014
Miranda-Laferte Erick, Ewers David, Guzman Raul E, Jordan Nadine, Schmidt Silke, Hidalgo Patricia
Abstract excerpt
The β-subunit associates with the α1 pore-forming subunit of high voltage-activated calcium channels and modulates several aspects of ion conduction. Four β-subunits are encoded by four different genes with multiple splice variants. Only two members of this family, β2a and β2e, associate with the plasma membrane in the absence of the α1-subunit. Palmitoylation on a di-cysteine motif located at the N terminus of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.