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Article

Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation.

The Journal of general physiology - 1 Mar 2009

Findeisen Felix, Minor Daniel L

Abstract excerpt

Two processes dominate voltage-gated calcium channel (Ca(V)) inactivation: voltage-dependent inactivation (VDI) and calcium-dependent inactivation (CDI). The Ca(V)beta/Ca(V)alpha(1)-I-II loop and Ca(2+)/calmodulin (CaM)/Ca(V)alpha(1)-C-terminal tail complexes have been shown to modulate each, respectively. Nevertheless, how each complex couples to the pore and whether each affects inactivation independently have...

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Identifiers

PMID: 19237593
DOI: 10.1085/jgp.200810143
PMCID: PMC2654080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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