Article
Ca(V)1.2 I-II linker structure and Timothy syndrome.
Channels (Austin, Tex.) - 1 Jan 2000
Almagor Lior, Chomsky-Hecht Orna, Ben-Mocha Adva, Hendin-Barak Doran, Dascal Nathan, Hirsch Joel A
Abstract excerpt
Ca(V) channels are multi-subunit protein complexes that enable inward cellular Ca(2+) currents in response to membrane depolarization. We recently described structure-function studies of the intracellular α1 subunit domain I-II linker, directly downstream of domain IS6. The results show the extent of the linker's helical structure to be subfamily dependent, as dictated by highly conserved primary sequence...
Topics
- Animals
- Autistic Disorder
- Calcium Channels, L-Type
- Humans
- Ion Channel Gating
- Long QT Syndrome
- Mutation
- Protein Structure, Secondary
- Structure-Activity Relationship
- Syndactyly
- Xenopus