Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ca(V)1.2 I-II linker structure and Timothy syndrome.

Channels (Austin, Tex.) - 1 Jan 2000

Almagor Lior, Chomsky-Hecht Orna, Ben-Mocha Adva, Hendin-Barak Doran, Dascal Nathan, Hirsch Joel A

Abstract excerpt

Ca(V) channels are multi-subunit protein complexes that enable inward cellular Ca(2+) currents in response to membrane depolarization. We recently described structure-function studies of the intracellular α1 subunit domain I-II linker, directly downstream of domain IS6. The results show the extent of the linker's helical structure to be subfamily dependent, as dictated by highly conserved primary sequence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autistic Disorder
Share to Calcium Channels, L-Type
Share to Ion Channel Gating

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Long QT Syndrome

Share to Protein Structure, Secondary

Share to Structure-Activity Relationship

Share to Syndactyly

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 22990809
DOI: 10.4161/chan.22078
PMCID: PMC3536733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ca(V)1.2 I-II linker structure and Timothy syndrome.PMID 22990809Read ↗

The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.Semantic proximity Read ↗

Ca <sub>V</sub> 1.2 channelopathic mutations evoke diverse pathophysiological mechanismsSemantic proximity Read ↗

L-type Ca2+ channel function during Timothy syndrome.Semantic proximity Read ↗

CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms.Semantic proximity Read ↗

Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation.Semantic proximity Read ↗

Introduction into Ca(v)2.1 of the homologous mutation of Ca(v)1.2 causing the Timothy syndrome questions the role of V421 in the phenotypic definition of P-type Ca(2+) channel.Semantic proximity Read ↗

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.Semantic proximity Read ↗

Functional characterization of a novel de novo CACNA1C pathogenic variant in a patient with neurodevelopmental disorder.Semantic proximity Read ↗

A specific tryptophan in the I-II linker is a key determinant of beta-subunit binding and modulation in Ca(V)2.3 calcium channels.Semantic proximity Read ↗

Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivationSemantic proximity Read ↗

The S4---S5 linker - gearbox of TRP channel gating.Semantic proximity Read ↗

An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.