Article

Investigating the Functional Role of the DI-DII Linker in Nav1.5 Channel Function

2024-12-05

Abstract excerpt

The cardiac voltage-gated sodium channel, Nav1.5 initiates the cardiac action potential. Its dysfunction can lead to dangerous arrhythmias, sudden cardiac arrest, and death. The functional Nav1.5 core consists of four homologous repeats (I, II, III, and IV), each formed from a voltage sensing and a pore domain. The channel also contains three cytoplasmic linkers (I-II, II-III, and III-IV). While Nav1.5 structures...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be1721fc-1558-52e6-b819-42c792d18216
DOI: 10.1101/2024.12.01.626264

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigating the Functional Role of the DI-DII Linker in Nav1.5 Channel FunctionDOI 10.1101/2024.12.01.626264Read

Missense mutation causes multiple defects in Nav1.4 channel gating and leads to an SCN4A-associated overlap phenotype.Semantic proximity Read

A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Nav1.5 Gating PoresSemantic proximity Read

Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders.Semantic proximity Read

Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms.Semantic proximity Read

A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias.Semantic proximity Read

A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutationSemantic proximity Read

Cardiac Sodium Channel Mutations: Why so Many Phenotypes?Semantic proximity Read

Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations.Semantic proximity Read

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.Semantic proximity Read

A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation.Semantic proximity Read

The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.Semantic proximity Read

Changes in sodium channel gating produced by point mutations in a cytoplasmic linker.Semantic proximity Read