The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.

doi:10.1523/JNEUROSCI.5727-11.2012

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Article

The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 May 2012

Almagor Lior, Chomsky-Hecht Orna, Ben-Mocha Adva, Hendin-Barak Doran, Dascal Nathan, Hirsch Joel A

Abstract excerpt

Voltage-dependent calcium channels (VDCCs) allow the passage of Ca(2+) ions through cellular membranes in response to membrane depolarization. The channel pore-forming subunit, α1, and a regulatory subunit (Ca(V)β) form a high affinity complex where Ca(V)β binds to a α1 interacting domain in the intracellular linker between α1 membrane domains I and II (I-II linker). We determined crystal structures of Ca(V)β2...

Topics

Amino Acid Sequence
Animals
Biophysics
Calcium
Calcium Channels
Crystallography
Extracellular Fluid
Ion Channel Gating
Membrane Potentials
Microinjections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Molecular Sequence Data

Mutation

Oocytes

Protein Conformation

Protein Structure, Secondary

Protein Structure, Tertiary

Rabbits

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Identifiers

PMID: 22649239
DOI: 10.1523/JNEUROSCI.5727-11.2012
PMCID: PMC6703595

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The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.PMID 22649239Read ↗

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