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Article

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Cell reports - 30 Jun 2015

Begun Jakob, Lassen Kara G, Jijon Humberto B, Baxt Leigh A, Goel Gautam, Heath Robert J, Ng Aylwin, Tam Jenny M, Kuo Szu-Yu, Villablanca Eduardo J, Fagbami Lola, Oosting Marije, Kumar Vinod, Schenone Monica, Carr Steven A, Joosten Leo A B, Vyas Jatin M, Daly Mark J, Netea Mihai G, Brown Gordon D, Wijmenga Cisca, Xavier Ramnik J

Abstract excerpt

The polymorphism ATG16L1 T300A, associated with increased risk of Crohn's disease, impairs pathogen defense mechanisms including selective autophagy, but specific pathway interactions altered by the risk allele remain unknown. Here, we use perturbational profiling of human peripheral blood cells to reveal that CLEC12A is regulated in an ATG16L1-T300A-dependent manner. Antibacterial autophagy is impaired in...

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Source

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Identifiers

PMID: 26095365
DOI: 10.1016/j.celrep.2015.05.045
PMCID: PMC4507440

Genes

CLEC12A
ATG16L1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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