Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.

doi:10.1002/ibd.21868

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Article

Digesting the genetics of inflammatory bowel disease: insights from studies of autophagy risk genes.

Inflammatory bowel diseases - 1 Apr 2012

Kabi Amrita, Nickerson Kourtney P, Homer Craig R, McDonald Christine

Abstract excerpt

The success of genetic analyses identifying multiple loci associated with inflammatory bowel disease (IBD) susceptibility has resulted in the identification of several risk genes linked to a common cellular process called autophagy. Autophagy is a process involving the encapsulation of cytosolic cellular components in double-membrane vesicles, their subsequent lysosomal degradation, and recycling of the degraded...

Topics

Autophagy
Autophagy-Related Proteins
Carrier Proteins
Female
GTP-Binding Proteins
Genetic Predisposition to Disease
Humans
Inflammatory Bowel Diseases
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nod2 Signaling Adaptor Protein

Phagosomes

Polymorphism, Genetic

Protein Serine-Threonine Kinases

Receptors, Calcitriol

Risk

Source

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Identifiers

PMID: 21936032
DOI: 10.1002/ibd.21868
PMCID: PMC3245781

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