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Article

Cell Type- and Stimulation-Dependent Transcriptional Programs Regulated by Atg16L1 and Its Crohn's Disease Risk Variant T300A.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2020

Varma Mukund, Kadoki Motohiko, Lefkovith Ariel, Conway Kara L, Gao Kevin, Mohanan Vishnu, Tusi Betsabeh Khoramian, Graham Daniel B, Latorre Isabel J, Tolonen Andrew C, Khor Bernard, Ng Aylwin, Xavier Ramnik J

Abstract excerpt

Genome-wide association studies have identified common genetic variants impacting human diseases; however, there are indications that the functional consequences of genetic polymorphisms can be distinct depending on cell type-specific contexts, which produce divergent phenotypic outcomes. Thus, the functional impact of genetic variation and the underlying mechanisms of disease risk are modified by cell...

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Identifiers

PMID: 32522834
DOI: 10.4049/jimmunol.1900750
PMCID: PMC7364322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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