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Article

The Caribbean-Hispanic Alzheimer's disease brain transcriptome reveals ancestry-specific disease mechanisms.

Neurobiology of disease - 1 Jan 2023

Felsky Daniel, Santa-Maria Ismael, Cosacak Mehmet Ilyas, French Leon, Schneider Julie A, Bennett David A, De Jager Philip L, Kizil Caghan, Tosto Giuseppe

Abstract excerpt

Identifying ancestry-specific molecular profiles of late-onset Alzheimer's Disease (LOAD) in brain tissue is crucial to understand novel mechanisms and develop effective interventions in non-European, high-risk populations. We performed gene differential expression (DE) and consensus network-based analyses in RNA-sequencing data of postmortem brain tissue from 39 Caribbean Hispanics (CH). To identify...

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Identifiers

PMID: 36462719
DOI: 10.1016/j.nbd.2022.105938
PMCID: PMC10039465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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