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Article

Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues.

Epigenetics - 1 Jan 2015

Llanos Adana A M, Marian Catalin, Brasky Theodore M, Dumitrescu Ramona G, Liu Zhenhua, Mason Joel B, Makambi Kepher H, Spear Scott L, Kallakury Bhaskar V S, Freudenheim Jo L, Shields Peter G

Abstract excerpt

Genome-wide DNA hypomethylation is an early event in the carcinogenic process. Percent methylation of long interspersed nucleotide element-1 (LINE-1) is a biomarker of genome-wide methylation and is a potential biomarker for breast cancer. Understanding factors associated with percent LINE-1 DNA methylation in histologically normal tissues could provide insight into early stages of carcinogenesis. In a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26090795
DOI: 10.1080/15592294.2015.1062205
PMCID: PMC4623023

Genes

MTHFR
MTR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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