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Article

Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study.

Carcinogenesis - 1 Feb 2014

Deroo Lisa A, Bolick Sophia C E, Xu Zongli, Umbach David M, Shore David, Weinberg Clarice R, Sandler Dale P, Taylor Jack A

Abstract excerpt

Global decrease in DNA methylation is a common feature of cancer and is associated with genomic and chromosomal instability. Retrospective case-control studies have reported that cancer patients have lower global methylation levels in blood DNA than do controls. We used prospectively collected samples and a case-cohort study design to examine global DNA methylation and incident breast cancer in 294 cases and a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24130171
DOI: 10.1093/carcin/bgt342
PMCID: PMC3908748

Genes

MTHFR
MTRR
PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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