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Article

Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study.

Carcinogenesis - 1 Jul 2007

Xu Xinran, Gammon Marilie D, Zhang Heping, Wetmur James G, Rao Manlong, Teitelbaum Susan L, Britton Julie A, Neugut Alfred I, Santella Regina M, Chen Jia

Abstract excerpt

One-carbon metabolism facilitates the crosstalk between genetic and epigenetic processes and plays critical roles in both DNA methylation and DNA synthesis, making it a good candidate for studying the risk of breast cancer. We previously reported that polymorphisms in methylenetetrahydrofolate reductase (MTHFR) in one-carbon pathway were associated with breast cancer risk in the population-based Long Island...

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Source

Identifiers

PMID: 17372271
DOI: 10.1093/carcin/bgm061

Genes

MTHFR
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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