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Article

Association of dietary and genetic factors related to one-carbon metabolism with global methylation level of leukocyte DNA.

Cancer science - 1 Dec 2012

Ono Hiroe, Iwasaki Motoki, Kuchiba Aya, Kasuga Yoshio, Yokoyama Shiro, Onuma Hiroshi, Nishimura Hideki, Kusama Ritsu, Ohnami Sumiko, Sakamoto Hiromi, Yoshida Teruhiko, Tsugane Shoichiro

Abstract excerpt

Global hypomethylation of leukocyte DNA has been associated with an increased risk of cancer. As dietary and genetic factors related to one-carbon metabolism may influence both the methylation and synthesis of DNA, we investigated associations between these factors and the global methylation level of peripheral blood leukocyte DNA based on a cross-sectional study of 384 Japanese women. Dietary intake of folate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22957669
DOI: 10.1111/cas.12013
PMCID: PMC7659348

Genes

MTHFR
MTR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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