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Article

Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women.

PloS one - 1 Jan 2013

Nan Hongmei, Giovannucci Edward L, Wu Kana, Selhub Jacob, Paul Ligi, Rosner Bernard, Fuchs Charles S, Cho Eunyoung

Abstract excerpt

BACKGROUND: Abnormal one-carbon metabolism may lead to general genomic (global) hypomethylation, which may predispose an individual to the development of colorectal neoplasia. METHODS: We evaluated the association between pre-diagnostic leukocyte genomic DNA methylation level and the risk of colorectal cancer in a nested case-control study of 358 colorectal cancer cases and 661 matched controls within the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

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Identifiers

PMID: 23560049
DOI: 10.1371/journal.pone.0059455
PMCID: PMC3613344

Genes

NHS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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