Article
Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.
Alcoholism, clinical and experimental research - 1 Jul 2015
Kosobud Ann E K, Wetherill Leah, Plawecki Martin H, Kareken David A, Liang Tiebing, Nurnberger John L, Windisch Kyle, Xuei Xiaoling, Edenberg Howard J, Foroud Tatiana M, O'Connor Sean J
Abstract excerpt
BACKGROUND: Subjective perceptions of alcohol intoxication are associated with altered risk for alcohol abuse and dependence. Acute adaptation of these perceptions may influence such risk and may involve genes associated with pleasant perceptions or the relief of anxiety. This study assessed the effect of variation in the GABAA receptor genes GABRG1 and GABRA2 and recent drinking history on the acute adaptation...
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