Article
The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes.
Clinical toxicology (Philadelphia, Pa.) - 1 Apr 2012
Bae Kyung-Yeol, Kim Sung-Wan, Shin Hee-Young, Kim Jae-Min, Shin Il-Seon, Kim Seong-Jin, Kim Jong-Keun, Yoon Jin-Sang
Abstract excerpt
BACKGROUND: This study investigated the acute effects of ethanol and acetaldehyde on physiological responses in healthy men according to ALDH2 genotype by measuring them directly in human blood. METHODS: Twenty-four men, 12 with the ALDH2*1/*1 genotype and 12 with the ALDH2*1/*2 genotype, were selected. In a double-blind placebo-controlled crossover design, each subject was administered one of three doses of...
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