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Article

Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression.

Genes, brain, and behavior - 1 Jun 2008

Haughey H M, Ray L A, Finan P, Villanueva R, Niculescu M, Hutchison K E

Abstract excerpt

Gamma-aminobutyric acid A (GABA(A)) receptors moderate several of the behavioral effects of alcohol. In fact, recent studies have shown an association between the gene for the alpha2-subunit of the GABA(A) receptor (GABRA2) and alcoholism. In the present study, we examined the functional relevance of the GABRA2 gene in alcohol dependence by assessing brain GABRA2 mRNA and GABA(A)alpha2-subunit protein levels in...

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Source

Identifiers

PMID: 18005236
DOI: 10.1111/j.1601-183X.2007.00369.x

Genes

GABRA2

Provenance

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