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Article

A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000

Arias Albert J, Covault Jonathan, Feinn Richard, Pond Timothy, Yang Bao-Zhu, Ge Wenjing, Oncken Cheryl, Kranzler Henry R

Abstract excerpt

AIMS: Variation in genes encoding GABAA receptor subunits has been implicated in the risk of alcohol dependence (AD). We sought to replicate and extend previous findings of a moderating effect of single nucleotide polymorphisms (SNPs) in GABRA2 (which encodes the GABAA α-2 subunit) on the subjective effects of alcohol by examining SNPs in this and the adjacent GABRG1 gene on chromosome 4. METHODS: Fifty-two...

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Source

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Identifiers

PMID: 24166645
DOI: 10.1093/alcalc/agt163
PMCID: PMC3865816

Genes

GABRA2
GABRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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