Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.

Alcoholism, clinical and experimental research - 1 Dec 2017

Yang Bao-Zhu, Arias Albert J, Feinn Richard, Krystal John H, Gelernter Joel, Petrakis Ismene L

Abstract excerpt

BACKGROUND: The heritable risk for alcohol use disorder (AUD) is expressed partly through alterations in subjective alcohol response. In this study, we investigated the effects of 2 AUD-risk-associated single nucleotide polymorphisms, GABRA2 rs279858 and GRIK1 rs2832407, on the subjective response to alcohol administered intravenously to healthy social drinkers in a laboratory setting. METHODS: In total, 93...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Administration, Intravenous
Share to Central Nervous System Stimulants
Share to Cross-Over Studies
Share to Double-Blind Method
Share to Healthy Volunteers
Share to Hypnotics and Sedatives
Share to Receptors, GABA-A
Share to Receptors, Kainic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 29131352
DOI: 10.1111/acer.13516
PMCID: PMC5764175

Genes

GABRA2
GRIK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers.PMID 29131352Read ↗

Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals.Semantic proximity Read ↗

Role of GABRA2 in moderating subjective responses to alcohol.Semantic proximity Read ↗

A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration.Semantic proximity Read ↗

GABRA2 markers moderate the subjective effects of alcohol.Semantic proximity Read ↗

Subjective response as a consideration in the pharmacogenetics of alcoholism treatment.Semantic proximity Read ↗

Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.Semantic proximity Read ↗

Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking.Semantic proximity Read ↗

Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression.Semantic proximity Read ↗

The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving.Semantic proximity Read ↗

Associations among GABRG1, level of response to alcohol, and drinking behaviors.Semantic proximity Read ↗

Genetic differences in response to alcohol.Semantic proximity Read ↗

Pharmacogenetics of alcohol and alcohol dependence treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.