Lip cancer and pre-cancerous lesions harbor TP53 mutations, exhibit allelic loss at 9p, 9q, and 17p, but no BRAFV600E mutations.

doi:10.1007/s13277-015-3659-9

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Lip cancer and pre-cancerous lesions harbor TP53 mutations, exhibit allelic loss at 9p, 9q, and 17p, but no BRAFV600E mutations.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Nov 2015

Correa Gefter Thiago Batista, Bernardes Vanessa Fátima, de Sousa Silvia Ferreira, Diniz Marina Gonçalves, Salles José Maria Porcaro, Souza Renan Pedra, De-Paula Alfredo Maurício Batista, Gomez Ricardo Santiago, Gomes Carolina Cavalieri

Abstract excerpt

Molecular mechanisms of lip squamous cell carcinoma (LSCC) and actinic cheilitis (AC) are unclear. We aimed at assessing loss of heterozygosity (LOH) and TP53 and BRAF V600E mutations in these lesions. Formalin-fixed paraffin-embedded (FFPE) samples of 17 LSCC and 16 AC were included, with additional 5 fresh LSCC genotyped for TP53 mutations. LOH was assessed by six polymorphic markers located at 9p22, 9q22, and...

Topics

Adult
Aged
Aged, 80 and over
Cell Proliferation
Cheilitis
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 9
Exons
Female
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lip Neoplasms

Loss of Heterozygosity

Male

Middle Aged

Mutation

Proto-Oncogene Proteins B-raf

Source

Open in PubMed

Identifiers

PMID: 26084614
DOI: 10.1007/s13277-015-3659-9

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.