Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics - 1 Apr 2009

Chou Annie, Dekker Nusi, Jordan Richard C K

Abstract excerpt

OBJECTIVE: Activating mutations in the fibroblast growth factor receptor 3 (FGFR3) gene are responsible for several craniosynostosis and chondrodysplasia syndromes as well as some human cancers, including bladder and cervical carcinoma. Despite a high frequency in some benign skin disorders, FGFR3 mutations have not been reported in cutaneous malignancies. Actinic cheilitis (AC) is a sun-induced premalignancy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Immunoenzyme Techniques

Share to Point Mutation

Share to Polymerase Chain Reaction

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to Sunlight

Source

Open in PubMed Open full text

Identifiers

PMID: 19327639
DOI: 10.1016/j.tripleo.2008.12.050
PMCID: PMC2682427

Genes

FGFR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip.PMID 19327639Read ↗

FGFR3 mutations in benign skin tumors.Semantic proximity Read ↗

Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humansSemantic proximity Read ↗

Frequent FGFR3 and Ras Gene Mutations in Skin Tags or Acrochordons.Semantic proximity Read ↗

FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes.Semantic proximity Read ↗

High Frequency of FGFR3 Mutations in Adenoid Seborrheic KeratosesSemantic proximity Read ↗

Lip cancer and pre-cancerous lesions harbor TP53 mutations, exhibit allelic loss at 9p, 9q, and 17p, but no BRAFV600E mutations.Semantic proximity Read ↗

Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.Semantic proximity Read ↗

Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation.Semantic proximity Read ↗

Studies of genes involved in craniofacial development and tumorigenesis: FGF3 contributes to isolated oral clefts and may interact with PAX9.Semantic proximity Read ↗

FGFR3 Mutations and the Skin: Report of a Patient with a FGFR3 Gene Mutation, Acanthosis Nigricans, Hypochondroplasia and Hyperinsulinemia and Review of the LiteratureSemantic proximity Read ↗

Somatic PIK3CA mutations are present in multiple tissues of facial infiltrating lipomatosis.Semantic proximity Read ↗

FGFR3 mutations in seborrheic keratoses are already present in flat lesions and associated with age and localization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.