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Article

High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease.

Lancet (London, England) - 17 Sept 1994

Rehman I, Quinn A G, Healy E, Rees J L

Abstract excerpt

Actinic keratoses (AKs) are focal areas of dysplasia with low risk of progression to squamous cell cancer; many regress spontaneously. Using polymerase-chain-reaction microsatellite analysis, we found that loss of heterozygosity on several chromosome arms, including 17p, 17q, 9p, 9q, and 13q, was common in AKs. More than half the AKs examined showed loss of heterozygosity at four or more loci. The apparent...

Topics

Alleles
Carcinoma, Squamous Cell
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 9
DNA, Satellite
Gene Deletion
Genes, Tumor Suppressor
Genes, p53
Genetic Markers
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Keratosis

Polymerase Chain Reaction

Precancerous Conditions

Source

Identifiers

PMID: 7916075
DOI: 10.1016/s0140-6736(94)92343-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7916075-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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