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Cell-Type Specific Changes in DNA Methylation of SNCA Intron 1 in Synucleinopathy Brains

28 Apr 2021

Abstract excerpt

Parkinson’s disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies. SNCA gene is a major genetic risk factor for these diseases group, and dysregulation of its expression has been implicated in the genetic etiologies of several synucleinopathies. DNA methylation at CpG island (CGI) within SNCA intron 1 has been suggested as a regulatory mechanism of SNCA expression, and changes in...

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PMID: 33994928
DOI: 10.3389/fnins.2021.652226

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