Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation changes at SNCA intron 1 in patients with dementia with L ewy bodies

29 Sept 2016

Abstract excerpt

AIM: It is difficult to diagnose dementia with Lewy bodies (DLB) because it exhibits clinical and neuropathological overlap with both Alzheimer's disease and Parkinson's disease. The α-synuclein protein is a major component of Lewy bodies, and accumulation of α-synuclein aggregates causes synaptic dysfunction in DLB. Epigenetic changes at the synuclein alpha ( SNCA ) gene may be involved in DLB pathogenesis....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27685250
DOI: 10.1111/pcn.12462

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation changes at SNCA intron 1 in patients with dementia with L ewy bodiesPMID 27685250Read ↗

Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer’s Disease SubjectsSemantic proximity Read ↗

Cell-Type Specific Changes in DNA Methylation of SNCA Intron 1 in Synucleinopathy BrainsSemantic proximity Read ↗

Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort studySemantic proximity Read ↗

CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease.Semantic proximity Read ↗

SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson’s DiseaseSemantic proximity Read ↗

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s diseaseSemantic proximity Read ↗

Parkinson's disease correlates with promoter methylation in the α-synuclein gene.Semantic proximity Read ↗

Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body DiseaseSemantic proximity Read ↗

DNA Methylation of α-Synuclein Intron 1 Is Significantly Decreased in the Frontal Cortex of Parkinson's Individuals with GBA1 Mutations.Semantic proximity Read ↗

[Neurodegeneration and epigenetics].Semantic proximity Read ↗

Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.Semantic proximity Read ↗

Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.