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Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study

2025-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Lewy body (LB) diseases are an umbrella term encompassing a range of neurodegenerative conditions all characterized by the hallmark of intra-neuronal α-synuclein associated with the development of motor and cognitive dysfunction. In this study, we have conducted a large meta-analysis of DNA methylation across multiple cortical brain regions, in relation to increasing burden of LB pathology. Util...

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Literature Corpus work
9ac1056e-2a2e-512d-bd96-10ddefdc7c7b
DOI
10.1101/2025.03.13.25323837
Open publication

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Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort studyDOI 10.1101/2025.03.13.25323837
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