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Article

Parkinson's disease correlates with promoter methylation in the α-synuclein gene.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2015

Pihlstrøm Lasse, Berge Victoria, Rengmark Aina, Toft Mathias

Abstract excerpt

BACKGROUND: Genome-wide association studies have demonstrated association between SNCA variability and susceptibility to Parkinson's disease, but causal mechanisms are unclear. We hypothesized that risk variants affect methylation of a putative promoter in SNCA intron 1, previously highlighted in...

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 25545759
DOI: 10.1002/mds.26073

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25545759-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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