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Article

Upstream transcription factor 1 (USF1) polymorphisms associate with Alzheimer's disease-related neuropathological lesions: Tampere Autopsy Study.

Brain pathology (Zurich, Switzerland) - 1 Nov 2012

Isotalo Karita, Kok Eloise Helena, Luoto Teemu M, Haikonen Satu, Haapasalo Hannu, Lehtimäki Terho, Karhunen Pekka J

Abstract excerpt

The apolipoprotein E (APOE) gene associates with Alzheimer's disease (AD) and cholesterol levels. Upstream transcription factor 1 (USF1) regulates lipid metabolism genes, including APOE, and the AD Aβ-precursor protein. We investigated associations between 6 haplotype-tagging USF1 single-nucleotide polymorphisms (and haplotypes) and AD-related neuropathological lesions [senile plaques (SP), neurofibrillary...

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Identifiers

PMID: 22390463
DOI: 10.1111/j.1750-3639.2012.00586.x
PMCID: PMC8057645

Genes

APOE

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