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Article

The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease.

Human molecular genetics - 15 Sept 2014

Linnertz Colton, Lutz Michael W, Ervin John F, Allen Jawara, Miller Natalie R, Welsh-Bohmer Kathleen A, Roses Allen D, Chiba-Falek Ornit

Abstract excerpt

The molecular genetic basis that leads to Lewy Body (LB) pathology in 15-20% of Alzheimer disease cases (LBV/AD) was largely unknown. Alpha-synuclein (SNCA) and Leucine-rich repeat kinase2 (LRRK2) have been implicated in the pathogenesis of Parkinson's disease (PD), the prototype of LB spectrum disorders. We tested the association of SNCA variants with LB pathology in AD. We then stratified the SNCA association...

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Source

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Identifiers

PMID: 24777780
DOI: 10.1093/hmg/ddu196
PMCID: PMC4140463

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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