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Elevated mRNA Expression and Low Methylation of SNCA in Japanese Alzheimer’s Disease Subjects

26 Aug 2016

Abstract excerpt

Despite the continuing debate about the amyloid hypothesis in Alzheimer's disease (AD), the precise pathogenesis is still unclear. Mixed pathology is common and multiple different protein aggregates are seen in human postmortem brains. Aggregates consisting of the alpha-synuclein protein encoded by the Synuclein Alpha gene (SCNA) are common in both dementia with Lewy bodies and AD. We examined SNCA mRNA...

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PMID: 27567856
DOI: 10.3233/jad-160430

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