Article
Tumour necrosis factor alpha 308 G/A is a risk marker for the progression from high-grade lesions to invasive cervical cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Mar 2014
Sousa Hugo, Oliveira Sara, Santos Alexandra M, Catarino Raquel, Moutinho José, Medeiros Rui
Abstract excerpt
Tumour necrosis factor alpha (TNF-α) is a strong pro-inflammatory cytokine with important functions on immune response to viral infections. A single nucleotide polymorphism on the -308 position of the promoter region of TNFA gene characterised by a G > A transition has been associated with different TNF-α levels and therefore with differential susceptibility for the development several diseases. A cross-sectional...
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