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The impact of pharmacogenetics on radiation therapy outcome in cancer patients. A focus on DNA damage response genes.

Cancer treatment reviews - 1 Oct 2012

Borchiellini Delphine, Etienne-Grimaldi Marie-Christine, Thariat Juliette, Milano Gérard

Abstract excerpt

More than half of cancer patients are treated by radiation therapy, with a wide inter-patient variability in tumour response. Recent advances have been made in understanding molecular mechanisms that govern the behaviour of tumour cells and tissues exposed to ionizing radiation. Accumulating data suggest an important role of DNA damage response genes, including DNA repair (especially double-strand breaks),...

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Apoptosis
Cell Cycle
DNA Damage
DNA Repair
DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Treatment Outcome

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PMID: 22387145
DOI: 10.1016/j.ctrv.2012.02.004

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