Article
Genetic determinants of cocaine-associated agranulocytosis.
BMC research notes - 13 Jun 2015
Buxton Jane A, Omura John, Kuo Margot, Ross Colin, Tzemis Despina, Purssell Roy, Gardy Jennifer, Carleton Bruce
Abstract excerpt
BACKGROUND: Drug-induced agranulocytosis is a recognized adverse drug event associated with serious infectious complications. Levamisole is an antihelminthic and immunomodulator withdrawn from North American markets in 2005 after reports of agranulocytosis. Previous studies of levamisole, suggest that the human leukocyte antigen (HLA)-B27 confers a genetic predisposition to this adverse drug event. Since 2009,...
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