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Article

Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis.

The Journal of clinical psychiatry - 1 Apr 2011

Athanasiou Maria C, Dettling Michael, Cascorbi Ingolf, Mosyagin Igor, Salisbury Benjamin A, Pierz Kerri A, Zou Wei, Whalen Heidi, Malhotra Anil K, Lencz Todd, Gerson Stanton L, Kane John M, Reed Carol R

Abstract excerpt

OBJECTIVE: Clozapine is considered to be the most efficacious drug to treat schizophrenia, although it is underutilized, partially due to a side effect of agranulocytosis. This analysis of 74 candidate genes was designed to identify an association between sequence variants and clozapine-induced agranulocytosis (CIA). METHOD: Blood and medical history were collected for 33 CIA cases and 54 clozapine-treated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20868635
DOI: 10.4088/JCP.09m05527yel

Genes

DRD1
NTSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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