Article
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
Nature communications - 4 Sept 2014
Goldstein Jacqueline I, Jarskog L Fredrik, Hilliard Chris, Alfirevic Ana, Duncan Laramie, Fourches Denis, Huang Hailiang, Lek Monkol, Neale Benjamin M, Ripke Stephan, Shianna Kevin, Szatkiewicz Jin P, Tropsha Alexander, van den Oord Edwin J C G, Cascorbi Ingolf, Dettling Michael, Gazit Ephraim, Goff Donald C, Holden Arthur L, Kelly Deanna L, Malhotra Anil K, Nielsen Jimmi, Pirmohamed Munir, Rujescu Dan, Werge Thomas, Levy Deborah L, Josiassen Richard C, Kennedy James L, Lieberman Jeffrey A, Daly Mark J, Sullivan Patrick F
Abstract excerpt
Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug reaction occurring in up to 1% of treated individuals. Identifying genetic risk factors for CIAG could enable safer and more widespread use of clozapine. Here we perform the largest and most comprehensive genetic study of CIAG to...
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