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Genetic identification of undiagnosed benign ethnic neutropenia in patients receiving clozapine treatment

9 Dec 2024

Abstract excerpt

Background Clozapine therapy presents a risk of agranulocytosis, necessitating monitoring of white blood cell count. The detection of benign ethnic neutropenia (BEN), in which neutropenia can be present without an increased risk of infection, is particularly important in preventing unnecessary withdrawal of clozapine. BEN is strongly linked to the CC homozygote of the single nucleotide polymorphism rs2814778 in...

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PMID: 39648666
DOI: 10.1192/bjp.2024.236

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