Article
Startle reactivity and prepulse inhibition of the acoustic startle response are modulated by catechol-O-methyl-transferase Val(158) Met polymorphism in adults with 22q11 deletion syndrome.
Journal of psychopharmacology (Oxford, England) - 1 Dec 2012
de Koning Mariken B, Boot Erik, Bloemen Oswald J N, van Duin Esther D A, Abel Kathryn M, de Haan Lieuwe, Linszen Don H, van Amelsvoort Thérèse A M J
Abstract excerpt
22q11 deletion syndrome (22q11DS) is a genetic disorder caused by a microdeletion on chromosome 22, which includes the gene coding for catechol-O-methyl-transferase (COMT). High dopamine (DA) levels due to COMT haplo-insufficiency may be associated with the increased risk of developing schizophrenia in adults with 22q11DS. Reduced prepulse inhibition (PPI) of the acoustic startle response has been associated with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.