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Article

Independent genomewide screens identify the tumor suppressor VTRNA2-1 as a human epiallele responsive to periconceptional environment.

Genome biology - 11 Jun 2015

Silver Matt J, Kessler Noah J, Hennig Branwen J, Dominguez-Salas Paula, Laritsky Eleonora, Baker Maria S, Coarfa Cristian, Hernandez-Vargas Hector, Castelino Jovita M, Routledge Michael N, Gong Yun Yun, Herceg Zdenko, Lee Yong Sun, Lee Kwanbok, Moore Sophie E, Fulford Anthony J, Prentice Andrew M, Waterland Robert A

Abstract excerpt

BACKGROUND: Interindividual epigenetic variation that occurs systemically must be established prior to gastrulation in the very early embryo and, because it is systemic, can be assessed in easily biopsiable tissues. We employ two independent genome-wide approaches to search for such variants. RESULTS: First, we screen for metastable epialleles by performing genomewide bisulfite sequencing in peripheral blood...

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Identifiers

PMID: 26062908
DOI: 10.1186/s13059-015-0660-y
PMCID: PMC4464629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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