Article
Establishment of environmentally sensitive DNA methylation states in the very early human embryo.
Science advances - 1 Jul 2018
Kessler Noah J, Waterland Robert A, Prentice Andrew M, Silver Matt J
Abstract excerpt
The molecular mechanisms responsible for the developmental origins of later disease are currently unknown. We previously demonstrated that women's periconceptional nutrition predicts their offspring's DNA methylation at metastable epialleles (MEs). We present a genome-wide screen yielding 687 MEs and track their trajectories across nine developmental stages in human in vitro fertilization embryos. MEs exhibit...
Topics
- Adult
- Binding Sites
- Child, Preschool
- CpG Islands
- DNA Methylation
- Embryo, Mammalian
- Embryonic Development
- Female
- Fertilization in Vitro
- Humans
- Intestine, Small