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Article

VTRNA2-1: Genetic Variation, Heritable Methylation and Disease Association.

International journal of molecular sciences - 3 Mar 2021

Dugué Pierre-Antoine, Yu Chenglong, McKay Timothy, Wong Ee Ming, Joo Jihoon Eric, Tsimiklis Helen, Hammet Fleur, Mahmoodi Maryam, Theys Derrick, kConFab, Hopper John L, Giles Graham G, Milne Roger L, Steen Jason A, Dowty James G, Nguyen-Dumont Tu, Southey Melissa C

Abstract excerpt

VTRNA2-1 is a metastable epiallele with accumulating evidence that methylation at this region is heritable, modifiable and associated with disease including risk and progression of cancer. This study investigated the influence of genetic variation and other factors such as age and adult lifestyle on blood DNA methylation in this region. We first sequenced the VTRNA2-1 gene region in multiple-case breast cancer...

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Identifiers

PMID: 33802562
DOI: 10.3390/ijms22052535
PMCID: PMC7961504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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