Article
Loss of Drosophila Vps16A enhances autophagosome formation through reduced Tor activity.
Autophagy - 1 Jan 2015
Takáts Szabolcs, Varga Ágnes, Pircs Karolina, Juhász Gábor
Abstract excerpt
The HOPS tethering complex facilitates autophagosome-lysosome fusion by binding to Syx17 (Syntaxin 17), the autophagosomal SNARE. Here we show that loss of the core HOPS complex subunit Vps16A enhances autophagosome formation and slows down Drosophila development. Mechanistically, Tor kinase is less active in Vps16A mutants likely due to impaired endocytic and biosynthetic transport to the lysosome, a site of its...
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