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Article

Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain.

Cell reports - 24 Dec 2024

Hamamoto Kouta, Liang Xinwen, Ito Ayako, Lanza Matthew, Bui Van, Zhang Jiawen, Opozda David M, Hattori Tatsuya, Chen Longgui, Haddock David, Imamura Fumiaki, Wang Hong-Gang, Takahashi Yoshinori

Abstract excerpt

Macroautophagy (autophagy) involves the formation of phagophores that mature into autophagosomes. The impact of inhibiting autophagosome closure remains unclear. Here, we report the generation and analysis of mice with impaired autophagosome closure by targeting the ubiquitin E2 variant-like (UEVL) β strands of the endosomal sorting complex required for transport (ESCRT) I subunit VPS37A. The VPS37A UEVL mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39607828
DOI: 10.1016/j.celrep.2024.115016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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