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Article

The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates.

Autophagy - 1 May 2008

Lindmo Karine, Brech Andreas, Finley Kim D, Gaumer Sébastien, Contamine Didier, Rusten Tor Erik, Stenmark Harald

Abstract excerpt

Autophagy is involved in cellular clearance of aggregate-prone proteins, thereby having a cytoprotective function. Studies in yeast have shown that the PI 3-kinase Vps34 and its regulatory protein kinase Vps15 are important for autophagy, but the possible involvement of these proteins in autophagy in a multicellular animal has not been addressed genetically. Here, we have created a Drosophila deletion mutant of...

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Identifiers

PMID: 18326940
DOI: 10.4161/auto.5829

Genes

SQSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates.PMID 18326940Read ↗

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.Semantic proximity Read ↗

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal diseaseSemantic proximity Read ↗

A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole.Semantic proximity Read ↗

Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.Semantic proximity Read ↗

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