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Article

Autophagosomal Syntaxin17-dependent lysosomal degradation maintains neuronal function in Drosophila.

The Journal of cell biology - 13 May 2013

Takáts Szabolcs, Nagy Péter, Varga Ágnes, Pircs Karolina, Kárpáti Manuéla, Varga Kata, Kovács Attila L, Hegedűs Krisztina, Juhász Gábor

Abstract excerpt

During autophagy, phagophores capture portions of cytoplasm and form double-membrane autophagosomes to deliver cargo for lysosomal degradation. How autophagosomes gain competence to fuse with late endosomes and lysosomes is not known. In this paper, we show that Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23671310
DOI: 10.1083/jcb.201211160
PMCID: PMC3653357

Genes

VAMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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