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Article

Drosophila Atg16 promotes enteroendocrine cell differentiation via regulation of intestinal Slit/Robo signaling.

Development (Cambridge, England) - 1 Nov 2017

Nagy Péter, Szatmári Zsuzsanna, Sándor Gyöngyvér O, Lippai Mónika, Hegedűs Krisztina, Juhász Gábor

Abstract excerpt

Genetic variations of Atg16l1, Slit2 and Rab19 predispose to the development of inflammatory bowel disease (IBD), but the relationship between these mutations is unclear. Here we show that in Drosophila guts lacking the WD40 domain of Atg16, pre-enteroendocrine (pre-EE) cells accumulate that fail to differentiate into properly functioning secretory EE cells. Mechanistically, loss of Atg16 or its binding partner...

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Identifiers

PMID: 28982685
DOI: 10.1242/dev.147033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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