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Article

<i>Atg6</i> is required for multiple vesicle trafficking pathways and hematopoiesis in <i>Drosophila</i>

13 Feb 2013

Abstract excerpt

Atg6 (beclin 1 in mammals) is a core component of the Vps34 complex that is required for autophagy. Beclin 1 (Becn1) functions as a tumor suppressor, and Becn1(+/-) tumors in mice possess elevated cell stress and p62 levels, altered NF-κB signaling and genome instability. The tumor suppressor function of Becn1 has been attributed to its role in autophagy, and the potential functions of Atg6/Becn1 in other vesicle...

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PMID: 23406899
DOI: 10.1242/dev.089490

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