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Article

The two<i><i>C. elegans</i></i>ATG-16 homologs have partially redundant functions in the basal autophagy pathway

5 Dec 2013

Abstract excerpt

The presence of multiple homologs of the same yeast ATG genes endows an extra layer of complexity on the autophagic machinery in higher eukaryotes. The physiological function of individual homologs in the autophagy pathway remains poorly understood. Here we characterized the function of the two atg16 homologs, atg-16.1 and atg-16.2, in the autophagy pathway in C. elegans. We showed that atg-16.2 mutants exhibit a...

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PMID: 24185444
DOI: 10.4161/auto.26095

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